Flucloxacilline 500mg is a prescription-only oral antibiotic used to combat bacterial infections caused by penicillinase-producing staphylococci. Belonging to the beta-lactam class of medications, this semi-synthetic penicillin is specifically designed to resist enzymatic breakdown by certain resistant bacterial strains. It is commonly administered when first-line penicillin treatments prove ineffective.
This beta-lactam antibiotic is frequently prescribed for the treatment of infections involving the skin, soft tissues, bones, and joints. It is also indicated for respiratory tract infections and surgical prophylaxis in certain clinical scenarios. Flucloxacilline is particularly beneficial in treating conditions like cellulitis, osteomyelitis, infected wounds, and impetigo caused by methicillin-sensitive Staphylococcus aureus (MSSA).
The active compound interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This action inhibits the final transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death. Its resistance to beta-lactamase enzymes allows it to maintain efficacy in environments where standard penicillins would be degraded.
Although not classified as habit-forming, responsible use of flucloxacillin is essential to minimize antimicrobial resistance. It should only be used when prescribed by a licensed healthcare provider. Caution is advised in individuals with hepatic dysfunction, renal impairment, or a history of hypersensitivity to beta-lactam antibiotics. Long-term or repeated use may increase the risk of superinfection with non-susceptible organisms.
Common adverse effects may include gastrointestinal discomfort, such as nausea, vomiting, or diarrhea. Hypersensitivity reactions like rash, urticaria, or, rarely, anaphylaxis may occur in sensitive individuals. Hepatic dysfunction, including cholestatic jaundice or hepatitis, has been reported with prolonged usage. Any unusual symptoms should be promptly reported to a healthcare professional.
Store in a dry place below 25°C. Protect from light and moisture. Keep the capsules in their original packaging and out of reach of children. Do not use the medication beyond the expiration date indicated on the packaging.
Flucloxacilline 500mg is a penicillinase-resistant oral antibiotic suitable for treating staphylococcal infections affecting skin, bones, and respiratory structures. Its beta-lactamase stability enhances its clinical utility, especially where resistance to standard penicillins is present. Use is restricted to prescription-only access and should follow strict medical guidance.
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